Autoantibodies in Serum of Systemic Scleroderma Patients: Peptide-Based Epitope Mapping Indicates Increased Binding to Cytoplasmic Domains of CXCR3
Systemic sclerosis (SSc) is a severe chronic autoimmune disease with high morbidity and mortality.Sera of patients with SSc contain a large variety of autoantibody (aab) reactivities.Among these are functionally active aab that bind to G protein-coupled receptors (GPCR) such as C-X-C motif chemokine receptor 3 (CXCR3) and 4 (CXCR4).Aab binding to t